Blog

What is Acetaldehyde? November 23 2013

Sources of Acetaldehyde There are four main routes that bring acetaldehyde (abbreviated here as AH) into the human brain. These are alcohol consumption, Candida the yeast syndrome, exhaust from cars and trucks, and cigarette smoking. Ethanol (more commonly known as alcohol) is the chemical contained in beer, wine, liquor and liqueurs responsible for intoxication. Beverages serve as carriers to get ethanol into the drinkers brain, promoting a degree of intoxication. Once in the body, alcohol is broken down into carbon dioxide and water. But, this process takes time and occurs in several steps. The first step occurs primarily in the liver, although other organs such as the brain and kidney can also contribute. An enzyme called alcohol dehydrogenase converts alcohol into AH over time. Then another enzyme aldehyde dehydrogenase must break the AH down into acetate. Acetate can then provide fuel in cellular energy production. However, the conversion of AH to acetate does not always occur quickly in the body naturally and therein lies the problem.

Research over the last several decades has shown that the body tends to rapidly convert alcohol to AH, but then convert AH to acetate very slowly.  And depending on a persons genetics, nutritional status, and exposure to other chemicals, most people have difficulty rapidly detoxifying AH.


The second major route of AH into the brain is through its production by a yeast called Candida albicans. Candida is known to occur in the intestinal tract of virtually all humans to some degree. When present only in small amounts, being kept in check by a healthy immune system and the so-called friendly flora, such as Acidophilus and Bifidus bacteria, Candida is relatively harmless. Yet due to the modern overuse of antibiotics, birth control pills, and cortisone/prednisone drug therapy, as well as excessive stress (which naturally produces excess cortisone in the body), sugar consumption and malnutrition, millions of Americans now suffer from an excessive growth of Candida in their intestines: the so-called yeast syndrome.


Candida lives by fermenting sugars to produce energy. Unfortunately for the humans who harbor large colonies of Candida in their gut, the waste by-product of this sugar fermentation by Candida is AH. Biochemical research has shown that this AH may combine with red blood cells, proteins, enzymes, and other substances present in the gut or gut lining, and thus travel through the bloodstream to reach more distant parts of the body such as the brain.  Research has also shown that AH can then detach from the red blood cells or proteins it traveled with through the bloodstream, thus enabling AH to damage cells far from the site of its intestinal production by Candida. 
For those suffering from the yeast syndrome, the ingestion of beer, wine, and liqueurs provides a double-barreled dose of AH. Not only is the alcohol in these beverages turned into AH, but the malt and grain in beer and the sugar in wine and liqueurs provide excellent fuel for Candida to produce the energy it needs to live.  More AH is the inevitable by-product of the yeasts sugar fermentation.


When oil, gasoline, diesel fuel, and natural gas are burned, ending up in the air, AH is produced.  Thus, another major route of entry into the body for AH is through inhaling air laden with vehicle and factory exhaust. People who spend hours commuting in dense freeway traffic, professional drivers such as truck and taxi drivers in urban areas, and even those who live or work in heavily trafficked areas or near freeways or major streets are especially at risk for inhaling small but significant chronic levels of AH.
AH is also produced through the burning of tobacco. Thus, heavy cigarette smokers are also at risk of inhaling AH through the inhaled smoke. And while the amounts of AH inhaled through auto exhaust and cigarette smoke may be small compared to that from alcohol, research shows that low-dose chronic AH exposure may still be sufficient to gradually damage proteins, enzymes and other cellular structures in the brain and other organs.

How Acetaldehyde Damages the Brain There are many ways that acetaldehyde (AH) can gradually damage brain structure and function through chronic, low-dose AH exposure. The following are some of them.
Acetaldehyde alters red blood cell structure. It has been known since 1941 that AH easily combines with red blood cell membrane proteins to convert the red blood cells into a time-release capsule for AH, releasing the AH in the body far from the site where it attached to the red blood cell.  As this happens, however, the membrane covering the red blood cell becomes stiffer.  Yet in order to travel through the capillaries, which are the smallest blood vessels and which feed the trillions of individual cells, the red blood cell must be able to fold or deform. The average red blood cell diameter is 7 microns; yet a typical capillary is only 2 microns in diameter. Red blood cells
stiffened through chronic AH exposure will have difficulty deforming sufficiently to pass through capillaries. Consequently, red blood cell-carried oxygen to many cells is reduced.  (Our brains require 20% of all the oxygen we breathe!) In addition, the work of K.K. Tsuboi and colleagues has shown that AH forms stable combinations with
hemoglobin in red blood cells. This reduces the ability of red blood cells to accept, hold, and transport oxygen through the bloodstream, which is their primary function.

Acetaldehyde decreases the ability of the protein tubulin to assemble into microtubules.  Microtubules are long, thin, tube-like structures that serve several functions in the brain cell. They help provide structural support to the nerve cell, somewhat like girders in a bridge or a building, keeping the nerve cell and the dendrites semi-rigid. Dendrites are the feathery-looking extensions from the main body of the nerve cell which connect nerve cells to each other, with some neurons connecting through dendrites to as many as 100,000 other neurons. Microtubules also serve to transport nutrients and biochemical raw materials manufactured in the cell body to the dendrites. When this raw material transport is compromised, the dendrites will gradually atrophy and die off. Two classic examples of brain pathology involving degeneration of the dendrites in humans are chronic alcoholic brain damage and Alzheimers disease.


Acetaldehyde induces a deficiency of vitamin B1. Thiamin, or Vitamin B1, is so critical to brain and nerve function it is often called the nerve vitamin. AH has a very strong tendency to combine with B1, as the work of Herbert Sprince, M.D. (discussed below) has shown.  Unfortunately, in detoxifying AH through combination with it, B1 is
destroyed. Moderately severe B1 deficiency in humans leads to a group of symptoms called Wernicke-Korsakoff syndrome. This syndrome is characterized by mental confusion, poor memory, poor neuromuscular coordination, and visual disturbances. Its primary accepted cause is chronic alcoholism. B1 is also necessary for the production of ATP bioenergy in all body cells including the brain, and the brain must produce and use 20% of the bodys energy total, even while asleep.

Vitamin B1 is also essential for production of acetylcholine. Acetylcholine is one of the brains major neurotransmitters, facilitating optimal memory, mental focus and concentration, and learning. Alzheimers disease represents a rather extreme case of memory loss and impaired concentration due to destruction of acetylcholine-using brain cells. In a classic experiment reported in 1942, R.R. Williams and colleagues found that even mild B1 deficiency in humans continued over a long period of time (the experiment ran six months) produces symptoms including apathy, confusion, emotional instability, irritability, depression, feelings of impending doom, fatigue, insomnia, and headaches all symptoms of less-than-optimal brain function.


Acetaldehyde induces deficiencies of niacin and NAD. Niacin (Vitamin B3) is present in the human body primarily in its coenzyme form, NAD.1 NAD is involved in the majority of steps in which sugar and fat are burned for energy in all cells. NAD is normally the most plentiful vitamin coenzyme in the human brain. NAD is important as a catalyst in the production of many key, brain neurotransmitters, such as serotonin. Neurotransmitters are the biochemicals that allow nerve cells to communicate with each other. NAD is also the coenzyme that activates alcohol dehydrogenase and aldehyde dehydrogenase, the enzymes that break down alcohol and AH. Zinc is also required along with NAD to activate these two enzymes. Since the need for NAD in all cells is great, yet the supply is limited, NAD is normally recycled continually during cellular energy production. Yet, when NAD helps detoxify AH, this recycling of NAD is blocked, and an altered form of NAD called NADH accumulates, impairing cellular biochemistry in many ways. Thus, chronic AH exposure may produce a mild, functional, niacin/NAD deficiency, even in a person consuming a so-called balanced diet which meets RDA levels of niacin intake.

Extreme niacin deficiency produces the classic nutritional disease Pellegra with dramatic symptoms, both physical and mental. Since niacin is needed in large amounts for optimal brain function, a mild niacin deficiency tends to produce mostly psychological symptoms. These symptoms may include feeling fearful, apprehensive, suspicious, and worrying excessively with a gloomy, downcast, angry and depressed outlook. Headaches, insomnia, depression, agitation, and inability to concentrate may also occur. This profile certainly applies to many chronic alcoholics and Candida patients, who obviously suffer from long-term, mild AH exposure.

Acetaldehyde reduces Acetyl Coenzyme A and impairs cellular energy production. Pantothenic Acid (Vitamin B5) is one of the most critical vitamins for normal brain function. The active form of B5 is Coenzyme A. Coenzyme A in turn is combined with acetate in all cells to form Acetyl Coenzyme A. Acetyl Coenzyme A is perhaps the most pivotal single biochemical in all cellular biochemistry; both sugar and fat must be transformed into Acetyl Coenzyme A to power the Krebs cycle which produces 90% of all the energy used by every cell in the body, including brain cells. Unfortunately, for Acetyl Coenzyme A, however, AH has a strong affinity to combine with Acetyl Coenzyme A.

The work of biochemist H.P. Ammon has shown that AH suppresses the activity of Acetyl Coenzyme A in a dose-dependent fashion. He has also demonstrated that the energy-producing activity of cells falls in parallel with the declining levels of Acetyl Coenzyme A as the concentration of AH increases. The brain uses 20% of all body energy for normal function. Acetyl Coenzyme A is also necessary for the production of acetylcholine, the memory, learning and concentration neurotransmitter.

Acetaldehyde induces a deficiency of Pyridoxal-5-Phosphate (P5P). P5P is the major coenzyme necessary to form virtually all major brain neurotransmitters. It is involved in all transamination reactions, whereby cells may convert many different amino acids into each other to satisfy their ever-shifting amino acid needs.10 P5P is necessary to convert essential fatty acids into their final use forms, as well as to turn linoleic acid into the key, nerve cell-regulating biochemical, Prostaglandin E1.  P5P helps regulate magnesium entry into cells,16 and the level of excitability of nerve cells is strongly dependent upon their magnesium level. P5P is also necessary to convert vitamin B3, niacin/niacinamide, into the active coenzyme form, NAD.17 Unfortunately for P5P (and we humans who are so dependent on it), AH is known to strongly combine with the protein portion of P5P enzymes in a way that displaces the P5P portion of the molecule. This subjects P5P to an increased rate of destruction and results in abnormally low blood and tissue levels of this coenzyme.

Acetaldehyde unfavorably influences prostaglandin metabolism. Delta-6-Desaturase is the enzyme that converts the common fatty acid linoleic acid into gamma linolenic acid, which is totally absent from any typical diet. Gamma linolenic acid in turn is the only raw material that can be converted into prostaglandin E1. Prostaglandin E1 is a key regulatory biochemical for both nerve cells and the immune system. It also serves to regulate the production of the pro-inflammatory prostaglandin E2. Prostaglandin E1 prevents excessive production of prostaglandin E2 from the dietary fatty acid, arachidonic acid, which is plentiful in meat, poultry and dairy products. Researchers in
prostaglandin biochemistry have discovered, however, that AH is a powerful deactivator of Delta-6-Desaturase. AH thus tends to suppress gamma linolenic acid production, which in turn suppresses prostaglandin E1 production. Low prostaglandin E1 production takes the brakes off production of prostaglandin E2 and a related compound, TXB2, increasing their levels far above normal. The published research of David Horrobin, M.D., and psychiatrist Julian Lieb, has shown high levels of prostaglandin E2 and TXB2, coupled with low levels of prostaglandin E1, to be a major causal factor in some forms of depression.

Acetaldehyde promotes addiction to toxic substances. Perhaps one of the most surprising ways AH may alter normal brain function is due to its tendency to combine in the brain with two key neurotransmitters, dopamine and serotonin. When AH and dopamine combine, they form a condensation product called salsolinol. When AH combines with serotonin, another product called beta-carboline is formed. Salsolinol and beta-carboline are two of a group of inter-related and interconvertible compounds called tetrahydro-isoquinolines. The various tetrahydroisoquinolines which both animal and human research have shown to occur at high levels in the brains, spinal fluids, and urine of chronic alcoholics are closely related in structure, function, and addictive power to opiates!  Successfully detoxifying alcoholics have been shown to excrete especially high levels of these opiate-like chemicals in their urine.  Thus, these AH-generated, opiate-like biochemicals may at least partly explain why alcoholics are so addicted to alcohol, cigarette smokers to cigarettes, and Candida-sufferers to sugar, since all three of these conditions promote chronic excessive body AH levels.20 And, like opiates, these tetrahydroisoquinoline biochemicals would tend to promote lethargy, mental cloudiness and fogginess, depression, apathy, inability to concentrate, etc. These, of course, are symptoms common to both alcoholism and Candidiasis, the two conditions which would tend to generate the highest chronic AH levels in the body.  The difficulties discussed above that are caused by chronic AH toxicity should indicate to the reader that AH has a significant ability to compromise brain function. A partial summary of AHs damaging effects on brain function includes the following:

•    Impaired memory
•    Decreased ability to concentrate (brain fog)
•    Depression
•    Slowed reflexes
•    Lethargy and apathy
•    Heightened irritability
•    Decreased mental energy
•    Increased anxiety and panic reactions
•    Decreased sensory acuity
•    Increased tendency to alcohol, sugar, and cigarette addiction
•    Decreased sex drive
•    Increased PMS and breast swelling/tenderness in women.

How Nutrition Can Help

Fortunately, applied nutrition science offers some protection against chronic AH toxicity, even when it is not possible to completely avoid the four main offenders that promote AH in our bodies: alcohol, Candida, cigarettes, and heavy auto exhaust.

Avoid Hangovers


Hangovers have plagued human kind since the beginning. 
Think avoiding hangovers is just urban legend? There only a couple of ways to avoid a hangover, you can abstain from drinking alcohol or drink moderately and take FORGIVEN.

More than 75 percent of alcohol consumers have experienced a hangover at least once in their life; 15 percent have at least one every month; and 25 percent of college students feel symptoms weekly.

The formal name for a hangover is veisalgia, from the Norwegian word for “uneasiness following debauchery” (kveis) and the Greek word for “pain” (algia) — an appropriate title considering the uncomfortable symptoms experienced by the average drinker. The common hangover includes some or all of the following:


•    Headache
•    Poor sense of overall well-being
•    Sensitivity to light and sound
•    Diarrhea
•    Loss of appetite
•    Trembling
•    Nausea
•    Fatigue
•    Increased heart rate and blood pressure
•    Dehydration(dry mouth, extreme thirst, dry eyes)
•    Trouble concentrating
•    Anxiety
•    Difficulty sleeping
•    Weakness 

The most common symptoms are headache, fatigue and dehydration, and the least common is trembling. The severity and number of symptoms varies from person to person; however, it is generally true that the more alcohol a drinker consumes, the worse the hangover will be.
It usually takes five to seven cocktails over the course of four to six hours to cause a hangover for a light-to-moderate drinker (a man who drinks up to three alcoholic beverages a day or a woman who drinks up to one). It may take more alcohol for heavier drinkers because of increased tolerance.
Other than the number of drinks consumed, hangovers can be made worse by:
•    drinking on an empty stomach
•    lack of sleep
•    increased physical activity while drinking (dancing, for example)
•    dehydration before drinking
•    poor health
The reason for some symptoms isn’t fully understood, but research has led scientists to have a pretty good understanding of the primary causes of a hangover.


Don’t take our word for it, try it yourself and see what the Forgiven is all about!  Order yours today and relief is on the way!


Hangover Remedies- What's to know? November 23 2013

Hangover remedies are scoured throughout the Internet, but what is really the right information?  First let’s start off by acknowledging that alcoholic drinks are perhaps the most popular beverage in the world today. It is taken by people to experience a different kind of pleasure that can’t be obtained in other types of beverage. Unfortunately, after a night of fun, what comes after is a morning characterized by distasteful sensations to include nausea, lethargy, headache, dehydration and dysphoria; calling the need for some hangover remedies as soon as possible.

The severity of hangover symptoms vary from person to person and depends on the amount of “impurities” or toxic substances contained in the alcoholic drink. Some factors were found to increase the incidence of hangover; which includes drinking on an empty stomach, low water intake, impaired sleep pattern, heavy alcohol ingestion; therefore the best hangover remedies are ones directed to all of these factors.

People searching for the best hangover remedies may have stumbled on of the many techniques which are as follows:

Hangover Remedies that do not work!

1. Eating food rich in protein, carbohydrates and fats; before during and after drinking alcohol, enhances the body’s ability to break down and metabolize alcohol quickly and efficiently, rendering the alcohol incapable of being transported to vital organs of the body before they can cause unpleasant physiologic symptoms. This is believed to be the best hangover remedy used by alcohol lovers both as a preventive and curative measure.

2. Eat foods rich in starch and fructose such as crackers, honey, fruit salad, cereals and yogurts to impair the absorption process of alcohol; decreasing blood alcohol concentration levels.

3. Increase water intake to maintain hydration and help the body flush out alcohol byproducts called acetaldehyde through the urinary system. This is one of the best hangover remedies in terms of naturally maintaining the body’s hydration status.

4. Never consider drinking coffee. It promotes water excretion through the body’s elimination mechanisms, which will only compromise the body’s hydration status, eventually leading to dehydration.

5. Lime water combined with honey will provide a rich source of glucose that serves as an energy source for the brain to increase mental alertness.

6. Also make sure to take foods with high vitamin c content such as oranges and other citrus fruits to strengthen immunity and boost the body’s natural healing ability in effectively getting rid of physiologic imbalances that cause hangover symptoms.

7. Taking ginger or peppermint tea will enhance the functioning of the gastrointestinal system, offsetting digestive irritation symptoms such as nausea, vomiting and diarrhea.

8. You may also apply alternate warm and cold compress to your forehead to alleviate headache.

These home-made remedies have already been proven helpful and effective in alleviating hangover symptoms to some measure, yet they are still not proven and tested for safe usage by medical professionals.

Considered by many, Forgiven Alcohol Metabolizer is the best hangover remedy on the market

As a result of extensive effort exerted by scientists to come up with the best hangover remedies; a potent alcohol metabolizer in the form of Forgiven capsules has finally been brought to life. Forgiven is the perfect antidote for alcohol. If alcohol causes fluid and electrolyte imbalance, vitamin depletion and dehydration, leading to distasteful sensations; Forgiven capsules assist the body in going back to its normal state, leaving no room for hangover symptoms.

Learn more about one the best hangover remedies by far! Buy Forgiven and recommend Forgiven capsules to your friends! You are guaranteed to have a more pleasurable and enjoyable time together, without having to worry about what happens upon waking up in the morning. The directions are easy, just take a packet of Forgiven when you are done drinking (1 packet per 5-6 drinks) and Forgiven will sober your body 5x faster than its natural rate of decline thus preventing a hangover!


Hangover Cures Convenient Safe Effective November 23 2013

Many different hangover cures can be found online, but which ones are safe? To understand the answer we must define the problem. Hangover is the term most commonly used to refer to the group of unpleasant physiologic symptoms following ingestion of a large amount of alcohol. Aside from headache, photosensitivity, lethargy, irritability, nausea, diarrhea and thirst; dehydration is also common and is believed to be the most serious effect of heavy alcohol consumption due its potentially fatal complications. As a response to this condition, advancements in science and pharmacology developed hangover cures intended for alcohol consumers.

Furthermore, the severity of hangover symptoms depends on the specific concentration of alcohol in a beverage. For example, Tequila or Rum (the clear spirits) has a lower alcohol concentration compared to whiskey or brandy (the dark spirits). This depends upon how the distiller processes the beverage.

Hangover is usually caused by too much alcohol consumption in a short span of time which leads to excessive accumulation of toxic substances in the body; or alcohol ingestion on an empty stomach which will lead to faster intoxication.

If you will drink slowly over a specific period of time, your body will be able to keep up with alcohol metabolism demands; preventing an excessive increase in the blood alcohol concentration that induces intoxication. However, if you ingest alcohol more than your body can metabolize, that’s where hangover sets in.

Ingestion on an empty stomach increases the rate of alcohol intoxication. An empty stomach has increased amounts of acid; an acidic environment speeds up the alcohol absorption process, leading to a higher rate of intoxication.

Is a Hangover Cure Possible?

To combat the physiologic effects caused by hangover, alcohol drinkers resorted to a lot of hangover cures and remedies. To address dehydration, for instance, some people increase their intake of fluid in the form of water or juice drinks before sleeping or upon waking up. These will serve to replenish the fluid and electrolytes (ascorbic acid) lost upon alcohol absorption. Eating bananas is also a hangover cure option to restore potassium and fructose levels depleted by alcohol. Bananas contain magnesium as well, a mineral that prevents brain structures and chemicals from causing headache. It is also a naturally occurring antacid to combat nausea and vomiting. These are also they type of hangover cures that represent ineffective products on the market, including Noho Drink.

These hangover cures can be effective to some extent, yet they don’t guarantee full relief of the unpleasant symptoms; especially with the advancement of age. Elderly people are less able to tolerate alcohol intoxication and will less likely find hangover cures effective.

On the other hand, some people resort to unreliable hangover cures such as taking Bloody Mary mixed with other substances believed to relieve hangover symptoms; to no avail. In the most fundamental sense, the problems caused by ingesting alcohol can’t be solved by taking more alcohol.

 

Hangover Cures - Forgiven Alcohol Metabolizer

Nevertheless, there’s no reason to worry anymore. An ideal hangover cure in the form of a natural and chemical-free medication has now been made available in the market. This is called Forgiven; a product especially formulated to speed up the breakdown of alcohol and its by-products that induce the unpleasant body reactions. It contains nutrients and minerals that are guaranteed to get rid of all the disagreeable sensations associated with drinking alcohol; so you remain physically and mentally in control.

DRINK TONIGHT,
THINK TOMORROW,
TAKE FORGIVEN.